1.Objective: According to studies,Mulberry leaf extract support removing liver-fire for improving eyesight, adjusting blood sugar concentration, regulating glucose metabolism and keeping a healthy liver.
This clinical application validation experiment was specially carried out on a group of laying hens with fatty liver symptom to verify the above mentioned efficacy.
2. Materials: Mulberry leaf extract (DNJ content 0.5%), provided by Hunan Geneham Pharmaceutical Co., Ltd.
3. Site: In Guangdong XXX Agricultural Technology Co., Ltd. (Chicken house: G30, Batch: G1904, Day-old: 535-541) from 23 to 29 September, 2020.
4. Methods: 50,000 laying hens with fatty liver syndrome were chose in a 7 consecutive days drinking water trail with addition of DNJ(0.5%) 100g/ton water, concentrate feeding for 6hours in full day water intake (1kg/day), to observe and record the production performance indexes of laying hens. The feeding management as per routine management of the chicken house and no other drugs were added during this experiment.
5 .The test results : Table 1
Table 1 The improvement of dietary Mulberry leaf extract on productivity in Laying hens
| Production Phase | Average laying rate% | Unqualified egg rate% | Average egg weight, g/egg | The average mortality numberPer day |
| 20 days before the experiment |
83.7 |
17.9 |
56.9 |
26 |
| 7 days during the experiment |
81.1 |
20.2 |
57.1 |
24 |
| 20days after the experiment |
85.2 |
23.8 |
57.2 |
13 |
Table 2 The daily mortality status before and after treating fatty liver syndrome with Mulberry leaf extract
leaf extract
|
Time |
Before treatment |
During treatment |
After treatment（1-7day） |
After treatment（8-14D） |
|
1D |
27 |
49 |
22 |
16 |
|
2D |
18 |
27 |
16 |
15 |
|
3D |
25 |
20 |
21 |
8 |
|
4D |
23 |
22 |
19 |
16 |
|
5D |
24 |
16 |
16 |
12 |
|
6D |
28 |
18 |
17 |
15 |
|
7D |
42 |
15 |
14 |
9 |
|
7days Total |
187 |
167 |
125 |
91 |
Table 1 results show that: results in Table 1 show that
5.1 The drinking water with addition Mulberry leaf extracts 100g/ton water (or 200g/ ton feeding ) has a significant liver protection effect, it can quickly reduce the mortality caused by fatty liver syndrome with no effect on feed intake and egg weight.
Suggestions: In order to reduce the liver damage with high-energy dietary, lower lipid and protein additive volume, increase bran dosage in feeding at the onset is suggested.
5.2 Mulberry leaf extract can effectively control the declination of laying rate caused by fatty liver. Due to the progress of the disease during treatment, the laying rate further decreased; After treatment, the laying rate raised up significantly, it increased 4.1% compared with the rate during treatment and increased 1.5% compared with the rate before treatment.
5.3 After treatment with mulberry leaf extract, the egg weight slightly increased 0.3g/pc compared with the weight before treatment
5.4 Due to the chicken house’s requirements of printing codes on eggs, the egg select is stricter, the unqualified egg rate increased.
It can thus be concluded that: With the combination of regulating the nutrient concentration of feeding, mulberry leaf extract can control the fatty liver syndrome in laying hens effectively, and significantly reduce the mortality rate, increase the productivity, raise the egg weight; mulberry leaf extract has significant effect of clinically cure fatty liver syndrome, it is worth to be applied widely. For other hepatic disease, further clinical verification is needed.
Anatomy picture at the onset
Post time: Dec-31-2020